TY - JOUR
T1 - Copy number analyses of DNA repair genes reveal the role of poly(ADP-ribose) polymerase (PARP) in tree longevity
AU - Aoyagi Blue, Yuta
AU - Kusumi, Junko
AU - Satake, Akiko
N1 - Funding Information:
We would like to thank Dr. Mizuki Ohno and Dr. Eriko Sasaki for helpful discussions and comments on this study. This study was funded by JSPS KAKENHI ( JP26251042 ; JP17H06478 ) to A.S.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/7/23
Y1 - 2021/7/23
N2 - Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However, the role of DNA repair in the lifespan of plants remains poorly understood. Using the recent accumulation of the complete genome sequences of diverse plant species, we performed systematic comparative analyses of the copy number variations of DNA repair genes in 61 plant species with different lifespans. Among 121 DNA repair gene families, PARP gene family was identified as a unique gene that exhibits significant expansion in trees compared to annual and perennial herbs. Among three paralogs of plant PARPs, PARP1 showed a close association with growth rate. PARPs catalyze poly(ADP-ribosyl)ation and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between plants and animals.
AB - Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However, the role of DNA repair in the lifespan of plants remains poorly understood. Using the recent accumulation of the complete genome sequences of diverse plant species, we performed systematic comparative analyses of the copy number variations of DNA repair genes in 61 plant species with different lifespans. Among 121 DNA repair gene families, PARP gene family was identified as a unique gene that exhibits significant expansion in trees compared to annual and perennial herbs. Among three paralogs of plant PARPs, PARP1 showed a close association with growth rate. PARPs catalyze poly(ADP-ribosyl)ation and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between plants and animals.
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U2 - 10.1016/j.isci.2021.102779
DO - 10.1016/j.isci.2021.102779
M3 - Article
AN - SCOPUS:85109575979
SN - 2589-0042
VL - 24
JO - iScience
JF - iScience
IS - 7
M1 - 102779
ER -