Copper-mediated direct C(sp3)-H and C(sp2)-H acetoxylation

Zhen Wang, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


A copper-mediated terminal position-selective C-(sp3)-H acetoxylation using a bidentate directing group and AgOAc as an oxidant was achieved. This reaction has high functional group tolerance and is not affected by steric hindrance. The reaction proceeds in excellent yield, even in gram scale, and the directing group can be removed after the reaction. Aromatic C(sp2)-H acetoxylation also proceeded under similar reaction conditions.

Original languageEnglish
Pages (from-to)4790-4793
Number of pages4
JournalOrganic letters
Issue number18
Publication statusPublished - Sept 19 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Copper-mediated direct C(sp3)-H and C(sp2)-H acetoxylation'. Together they form a unique fingerprint.

Cite this