Copper-catalyzed C-H alkoxylation of azoles

Noriaki Takemura, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


We achieved copper-catalyzed intramolecular and intermolecular alkoxylation of azoles. This reaction is a rare example of transition-metal-catalyzed C-H alkoxylation of heteroaromatic compounds. In addition, the alkoxylation reaction proceeded well even in gram scale. In most intermolecular alkoxylations, the use of an excess amount of alcohols (in some cases, alcohols are used as a solvent) is indispensable to efficiently promote the alkoxylation reaction, but this alkoxylation reaction proceeded using only 1 equiv of alcohols.

Original languageEnglish
Pages (from-to)844-847
Number of pages4
JournalOrganic Letters
Issue number4
Publication statusPublished - Feb 15 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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