Copper-catalyzed benzylic C(sp3)-H alkoxylation of heterocyclic compounds

Noriaki Takemura, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


We achieved intra- and intermolecular C(sp3)-H alkoxylation of benzylic positions of heteroaromatic compounds using CuBrn (n = 1, 2)/5,6-dimethylphenanthroline (or 4,7-dimethoxyphenanthroline) and ( tBuO)2 as a catalyst and an oxidant, respectively. The reaction proceeded at both terminal and internal benzylic positions of the alkyl groups. The intramolecular alkoxylation was performed on a gram scale. This journal is

Original languageEnglish
Pages (from-to)2528-2532
Number of pages5
JournalOrganic and Biomolecular Chemistry
Issue number16
Publication statusPublished - Apr 28 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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