TY - JOUR
T1 - Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats
AU - Oka, Takakazu
AU - Oka, Kae
AU - Saper, Clifford B.
N1 - Funding Information:
The authors are grateful to Dr. T. Maruyama, Ono Pharmaceutical Co. (Osaka, Japan), for providing the EP receptor agonists. This study was supported by USPHS grant NS33987.
PY - 2003/4/11
Y1 - 2003/4/11
N2 - Prostaglandin E2 (PGE2) is thought to be a principal fever mediator. There are four subtypes of PGE (EP) receptors, EP1-EP4. We investigated which EP receptors mediate PGE2-induced hyperthermia by injecting selective EP receptor agonists into the rat lateral cerebral ventricle under unrestrained condition. ONO-DI-004, an EP1 receptor agonist, increased the core temperature (Tc) in a dose-dependent manner (1.6±0.1°C at 20 nmol, with the peak 30 min after injection) with a time course similar to PGE2-induced hyperthermia. ONO-AE1-259-01 (20 nmol), an EP2 receptor agonist, did not change the Tc. ONO-AE-248 (20 nmol), an EP3 receptor agonist, also increased the Tc. However, the peak effect was delayed (1.2±0.2°C, 50 min after injection) compared to PGE2. In contrast, ONO-AE1-329, an EP4 receptor agonist, decreased the Tc. These findings suggest that the EP1, EP3, and EP4 receptors all may contribute to the thermoregulatory response to PGE2, but each may have a different role.
AB - Prostaglandin E2 (PGE2) is thought to be a principal fever mediator. There are four subtypes of PGE (EP) receptors, EP1-EP4. We investigated which EP receptors mediate PGE2-induced hyperthermia by injecting selective EP receptor agonists into the rat lateral cerebral ventricle under unrestrained condition. ONO-DI-004, an EP1 receptor agonist, increased the core temperature (Tc) in a dose-dependent manner (1.6±0.1°C at 20 nmol, with the peak 30 min after injection) with a time course similar to PGE2-induced hyperthermia. ONO-AE1-259-01 (20 nmol), an EP2 receptor agonist, did not change the Tc. ONO-AE-248 (20 nmol), an EP3 receptor agonist, also increased the Tc. However, the peak effect was delayed (1.2±0.2°C, 50 min after injection) compared to PGE2. In contrast, ONO-AE1-329, an EP4 receptor agonist, decreased the Tc. These findings suggest that the EP1, EP3, and EP4 receptors all may contribute to the thermoregulatory response to PGE2, but each may have a different role.
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U2 - 10.1016/S0006-8993(03)02268-6
DO - 10.1016/S0006-8993(03)02268-6
M3 - Article
C2 - 12663095
AN - SCOPUS:0037432521
SN - 0006-8993
VL - 968
SP - 256
EP - 262
JO - Brain Research
JF - Brain Research
IS - 2
ER -