Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats

Takakazu Oka, Kae Oka, Clifford B. Saper

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46 Citations (Scopus)


Prostaglandin E2 (PGE2) is thought to be a principal fever mediator. There are four subtypes of PGE (EP) receptors, EP1-EP4. We investigated which EP receptors mediate PGE2-induced hyperthermia by injecting selective EP receptor agonists into the rat lateral cerebral ventricle under unrestrained condition. ONO-DI-004, an EP1 receptor agonist, increased the core temperature (Tc) in a dose-dependent manner (1.6±0.1°C at 20 nmol, with the peak 30 min after injection) with a time course similar to PGE2-induced hyperthermia. ONO-AE1-259-01 (20 nmol), an EP2 receptor agonist, did not change the Tc. ONO-AE-248 (20 nmol), an EP3 receptor agonist, also increased the Tc. However, the peak effect was delayed (1.2±0.2°C, 50 min after injection) compared to PGE2. In contrast, ONO-AE1-329, an EP4 receptor agonist, decreased the Tc. These findings suggest that the EP1, EP3, and EP4 receptors all may contribute to the thermoregulatory response to PGE2, but each may have a different role.

Original languageEnglish
Pages (from-to)256-262
Number of pages7
JournalBrain Research
Issue number2
Publication statusPublished - Apr 11 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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