Continuous production of l-serine by immobilized growing Corynebacterium glycinophilum cells

Takaaki Tanaka, Keiichi Yamamoto, Sirintornthep Towprayoon, Hiroki Nakajima, Kenji Sonomoto, Kenzo Yokozeki, Koji Kubota, Atsuo Tanaka

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Auxotrophic mutant cells of Corynebacterium glycinophilum with high l-serine production activity were immobilized by entrapment with various gel materials, such as synthetic prepolymers and natural polysaccharides. The entrapped cells were used for estimation of l-serine productivity in a medium supplemented with glycine as a precursor. Based on the above criteria, including cell growth in gels and cell leakage from gels, calcium alginate was the most suitable gel material. Continuous l-serine fermentation with calcium alginate-entrapped growing cells was successfully achieved in an air-bubbled reactor for at least 13 days.

Original languageEnglish
Pages (from-to)564-568
Number of pages5
JournalApplied Microbiology and Biotechnology
Issue number6
Publication statusPublished - Jun 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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