Construction of a transplantable tissue-engineered artificial peritoneum

H. Kuga, T. Morisaki, K. Nakamura, H. Onishi, T. Matsuda, K. Sueishi, M. Tanaka, M. Katano

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Background: Peritoneal defects lead to serious postoperative problems. Thus the development of physiological material to cover peritoneal defects is very desirable. Aim: The aim of this study was to develop a transplantable artificial peritoneum. Method: The artificial peritoneum consisted of collagen gel, fibroblasts, and mesothelial cells, and histological features were analyzed. The artificial peritoneum at the site of a peritoneal defect in the rat was transplanted to the abdominal wall. Results: Histological examination revealed that the artificial peritoneum consisted of a flat mesothelial monolayer upon a stromal matrix. All transplanted artificial peritoneums adapted well to the host and prevented severe adhesion. Conclusion: Our artificial peritoneum may be a useful transplantable bioengineered material for repair of surgical peritoneal defects.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalEuropean Surgical Research
Issue number5
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Surgery


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