A ganglioside molecular species SJG-1 has been obtained from the n- hexane soluble lipid fraction of the chloroform/ methanol extract of the sea cucumber Stichopus japonicus. On the basis of chemical and spectroscopic evidence, the structure of SJG-1 has been determined. SJG-1 possesses an N- glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine-type long-chain bases as major ceramide components. The ganglioside SJG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.
|Number of pages
|European Journal of Organic Chemistry
|Published - Nov 1999
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry