TY - JOUR
T1 - Conserved amino acid residues in ribosome-inactivating proteins from plants
AU - Funatsu, G.
AU - Islam, MR
AU - Minami, Y.
AU - Sung-Sil, K.
AU - Kimura, M.
PY - 1991
Y1 - 1991
N2 - The amino acid sequences of eleeven RIPs sequenced to date have been compared in the expectation that this would be useful in the location of functionally and/or structurally important sites of these molecules. In addition to several highly conserved hydrophobic amino acids, thirteen absolutely conserved residues have been found in ricin A-chain: Tyr21, Phe24, Arg29, Tyr80, Tyr123, Gly140, Ala165, Glu177, Ala178, Glu208, Asn209 and Trp211. The role of these residues as well as of the C-terminal region have been discussed based on the results of chemical and enzymatic modifications, site-directed mutagenesis, and deletion studies.
AB - The amino acid sequences of eleeven RIPs sequenced to date have been compared in the expectation that this would be useful in the location of functionally and/or structurally important sites of these molecules. In addition to several highly conserved hydrophobic amino acids, thirteen absolutely conserved residues have been found in ricin A-chain: Tyr21, Phe24, Arg29, Tyr80, Tyr123, Gly140, Ala165, Glu177, Ala178, Glu208, Asn209 and Trp211. The role of these residues as well as of the C-terminal region have been discussed based on the results of chemical and enzymatic modifications, site-directed mutagenesis, and deletion studies.
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U2 - 10.1016/0300-9084(91)90160-3
DO - 10.1016/0300-9084(91)90160-3
M3 - Article
C2 - 1742358
AN - SCOPUS:0025937466
SN - 0300-9084
VL - 73
SP - 1157
EP - 1161
JO - Biochimie
JF - Biochimie
IS - 7-8
ER -