TY - JOUR
T1 - Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women
T2 - Central pathologic review and treatment outcome
AU - Kaku, Tsunehisa
AU - Yoshikawa, Hiroyuki
AU - Tsuda, Hitoshi
AU - Sakamoto, Atsuhiko
AU - Fukunaga, Masaharu
AU - Kuwabara, Yoshinori
AU - Hataeg, Masaki
AU - Kodama, Shoji
AU - Kuzuya, Kazuo
AU - Sato, Shinji
AU - Nishimura, Toshinobu
AU - Hiura, Masamichi
AU - Nakano, Hitoo
AU - Iwasaka, Tsuyoshi
AU - Miyazaki, Koji
AU - Kamura, Toshiharu
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Research of Cancer Treatment from the Ministry of Health and Welfare of Japan (number 10-12). The authors acknowledge the support and assistance of the Japan Gynecologic Study Group, namely the following collaborators: Y. Kikuchi (National Defense Medical College, Tokorozawa, Japan), R. Kudo and S. Sagae (Sapporo Medical University, Sapporo, Japan), K. Fujiwara (Kawasaki Medical School, Kurashiki, Japan), H. Sasaki (The Jikei University School of Medicine, Tokyo, Japan), K. Yamamoto (Kinki University School of Medicine, Sayama, Japan), and H. Yahata (Kyushu University, Fukuoka, Japan).
PY - 2001/6/10
Y1 - 2001/6/10
N2 - Thirty-nine patients with endometrioid adenocarcinoma (EA) and atypical hyperplasia (AH) of the endometrium who received conservative treatment to preserve fertility were collected from member institutions of the Japan Gynecologic Oncology Study Group. Twenty-nine and ten were originally diagnosed with EA without myometrial invasion and AH, respectively. We performed a central pathological review to make definite diagnoses, and the diagnosis of EA in 29 cases was changed to AH in ten, complex hyperplasia in three and atypical polypoid adenomyoma in three, and AH in ten was changed to EA in one and simple hyperplasia in one. Nine of 12 women (75%) with EA and 15 of 18 women (83%) with AH had an initial response to medroxyprogesterone acetate (MPA) treatment. Two of nine responders with EA later developed relapse, and one of them had metastasis to the left obturator lymph node. Two became pregnant, and one delivered one full-term infant. One of the responders with AH had a relapse in the endometrium. Five became pregnant, and four delivered four normal infants. The young women with endometrial carcinoma localized in the endometrium who wish to preserve fertility may be treated as successfully with MPA as those with AH.
AB - Thirty-nine patients with endometrioid adenocarcinoma (EA) and atypical hyperplasia (AH) of the endometrium who received conservative treatment to preserve fertility were collected from member institutions of the Japan Gynecologic Oncology Study Group. Twenty-nine and ten were originally diagnosed with EA without myometrial invasion and AH, respectively. We performed a central pathological review to make definite diagnoses, and the diagnosis of EA in 29 cases was changed to AH in ten, complex hyperplasia in three and atypical polypoid adenomyoma in three, and AH in ten was changed to EA in one and simple hyperplasia in one. Nine of 12 women (75%) with EA and 15 of 18 women (83%) with AH had an initial response to medroxyprogesterone acetate (MPA) treatment. Two of nine responders with EA later developed relapse, and one of them had metastasis to the left obturator lymph node. Two became pregnant, and one delivered one full-term infant. One of the responders with AH had a relapse in the endometrium. Five became pregnant, and four delivered four normal infants. The young women with endometrial carcinoma localized in the endometrium who wish to preserve fertility may be treated as successfully with MPA as those with AH.
UR - http://www.scopus.com/inward/record.url?scp=0035838118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035838118&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(01)00462-1
DO - 10.1016/S0304-3835(01)00462-1
M3 - Article
C2 - 11323097
AN - SCOPUS:0035838118
SN - 0304-3835
VL - 167
SP - 39
EP - 48
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
