TY - JOUR
T1 - Connexins in health and disease
AU - Yamasaki, Ryo
N1 - Funding Information:
This study was partly supported by a Health and Labor Sciences Research Grant on Intractable Diseases (H26-Nanchitou [Nan]-Ippan-074) from the Ministry of Health, Labor and Welfare, Japan; the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development (AMED); “Glial Assembly” Grants-in-Aid for Scientific Research on Innovative Areas (MEXT KAKENHI Grant Numbers 25117001 and 25117012) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; a Grant-in-Aid for Scientific Research (A) (JSPS KAKENHI Grant Number 16H02657), Grants-in-Aid for Scientific Research (C) (JSPS KAKENHI Grant Numbers 16K09694 and 26461295), a Grant-in-Aid for Exploratory Research (JSPS KAKENHI Grant Number 15K15341) and a Grant-in-Aid for Young Scientists (B) (JSPS KAKENHI Grant Number 15K19489) from the Japan Society for the Promotion of Science. We appreciate the assistance from The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences. We thank Ann Turnley, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
Publisher Copyright:
© 2018 Japanese Society for Neuroimmunology
PY - 2018/3
Y1 - 2018/3
N2 - Gap junctions or hemichannels are expressed on all cells in our body, and have a highly significant role in homeostasis and in disease states. There are 21 connexins found in humans and they have distinct characteristics that compensate for each other. The anatomical expression pattern also differs between each connexin; some of them are expressed together and some are not. Genetically mutated connexin genes induce inheritable diseases, but acquired disorders can also be caused by primary or secondary connexin dysfunctions. In the central nervous system, glial cells are the main connexin-expressing cells. They utilize connexin gap junctions to assemble glial networks. The present review not only describes the basic structures and functions of connexins, it also examines the relationships between connexins and their role in disease pathology.
AB - Gap junctions or hemichannels are expressed on all cells in our body, and have a highly significant role in homeostasis and in disease states. There are 21 connexins found in humans and they have distinct characteristics that compensate for each other. The anatomical expression pattern also differs between each connexin; some of them are expressed together and some are not. Genetically mutated connexin genes induce inheritable diseases, but acquired disorders can also be caused by primary or secondary connexin dysfunctions. In the central nervous system, glial cells are the main connexin-expressing cells. They utilize connexin gap junctions to assemble glial networks. The present review not only describes the basic structures and functions of connexins, it also examines the relationships between connexins and their role in disease pathology.
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U2 - 10.1111/cen3.12433
DO - 10.1111/cen3.12433
M3 - Review article
AN - SCOPUS:85043398436
SN - 1759-1961
VL - 9
SP - 30
EP - 36
JO - Clinical and Experimental Neuroimmunology
JF - Clinical and Experimental Neuroimmunology
ER -