Conjugated linoleic acid reduces body fats and cytokine levels of mice

Asuka Akahoshi, Yuki Goto, Kayoko Murao, Tomoko Miyazaki, Masao Yamasaki, Michiko Nonaka, Koji Yamada, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.

Original languageEnglish
Pages (from-to)916-920
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number4
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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