Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male

Eriko Sada; Hideho Henzan; Ryoko Ohtani; Ken Takase; Toshihiro Miyamoto; Takahiro Fukuda; Koji Nagafuji; Keita Yamauchi; Yasushi Takamatsu; Shoichi Inaba; Mine Harada

doi:10.1002/ajh.20255

Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male

Eriko Sada, Hideho Henzan, Ryoko Ohtani, Ken Takase, Toshihiro Miyamoto, Takahiro Fukuda, Koji Nagafuji, Keita Yamauchi, Yasushi Takamatsu, Shoichi Inaba, Mine Harada

Internal Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	American Journal of Hematology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1002/ajh.20255
Publication status	Published - Jan 2005

All Science Journal Classification (ASJC) codes

Hematology

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10.1002/ajh.20255

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title = "Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male",

abstract = "We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.",

author = "Eriko Sada and Hideho Henzan and Ryoko Ohtani and Ken Takase and Toshihiro Miyamoto and Takahiro Fukuda and Koji Nagafuji and Keita Yamauchi and Yasushi Takamatsu and Shoichi Inaba and Mine Harada",

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AU - Sada, Eriko

AU - Henzan, Hideho

AU - Ohtani, Ryoko

AU - Takase, Ken

AU - Miyamoto, Toshihiro

AU - Fukuda, Takahiro

AU - Nagafuji, Koji

AU - Yamauchi, Keita

AU - Takamatsu, Yasushi

AU - Inaba, Shoichi

AU - Harada, Mine

PY - 2005/1

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N2 - We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.

AB - We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.

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Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male

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