Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia

E. Azuma; S. Kojima; K. Kato; T. Matsuyama; Y. Yamada; N. Kondo; H. Sawada; M. Hanada; T. Shibata; N. Tabata; M. Watanabe; Y. Shimono; T. Deguchi; M. Umemoto; M. Higashikawa; H. Kawasaki; Y. Komada; M. Sakurai

doi:10.1038/sj.bmt.1700795

Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia

E. Azuma, S. Kojima, K. Kato, T. Matsuyama, Y. Yamada, N. Kondo, H. Sawada, M. Hanada, T. Shibata, N. Tabata, M. Watanabe, Y. Shimono, T. Deguchi, M. Umemoto, M. Higashikawa, H. Kawasaki, Y. Komada, M. Sakurai

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.

Original language	English
Pages (from-to)	1085-1087
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	19
Issue number	11
DOIs	https://doi.org/10.1038/sj.bmt.1700795
Publication status	Published - Jun 1 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology
Transplantation

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Azuma, E., Kojima, S., Kato, K., Matsuyama, T., Yamada, Y., Kondo, N., Sawada, H., Hanada, M., Shibata, T., Tabata, N., Watanabe, M., Shimono, Y., Deguchi, T., Umemoto, M., Higashikawa, M., Kawasaki, H., Komada, Y., & Sakurai, M. (1997). Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia. Bone Marrow Transplantation, 19(11), 1085-1087. https://doi.org/10.1038/sj.bmt.1700795

Azuma, E, Kojima, S, Kato, K, Matsuyama, T, Yamada, Y, Kondo, N, Sawada, H, Hanada, M, Shibata, T, Tabata, N, Watanabe, M, Shimono, Y, Deguchi, T, Umemoto, M, Higashikawa, M, Kawasaki, H, Komada, Y & Sakurai, M 1997, 'Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia', Bone Marrow Transplantation, vol. 19, no. 11, pp. 1085-1087. https://doi.org/10.1038/sj.bmt.1700795

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title = "Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia",

abstract = "Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.",

author = "E. Azuma and S. Kojima and K. Kato and T. Matsuyama and Y. Yamada and N. Kondo and H. Sawada and M. Hanada and T. Shibata and N. Tabata and M. Watanabe and Y. Shimono and T. Deguchi and M. Umemoto and M. Higashikawa and H. Kawasaki and Y. Komada and M. Sakurai",

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doi = "10.1038/sj.bmt.1700795",

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AU - Azuma, E.

AU - Kojima, S.

AU - Kato, K.

AU - Matsuyama, T.

AU - Yamada, Y.

AU - Kondo, N.

AU - Sawada, H.

AU - Hanada, M.

AU - Shibata, T.

AU - Tabata, N.

AU - Watanabe, M.

AU - Shimono, Y.

AU - Deguchi, T.

AU - Umemoto, M.

AU - Higashikawa, M.

AU - Kawasaki, H.

AU - Komada, Y.

AU - Sakurai, M.

PY - 1997/6/1

Y1 - 1997/6/1

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AB - Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.

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Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia

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