Concordance for neuroblastoma in monozygotic twins: Case report and review of the literature

Tatsuro Tajiri, Ryota Sozaki, Yoshiaki Kinoshita, Sakura Tanaka, Yuhki Koga, Aiko Suminoe, Toshiro Hara, Kenichi Kohashi, Yoshinao Oda, Kouji Masumoto, Miki Ohira, Akira Nakagawara, Tomoaki Taguchi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The patients were infant male twins born by cesarean delivery following a healthy pregnancy at 36 weeks' gestation to unrelated parents. At 4 months of age, twin 2 presented with hepatomegaly and a right suprarenal mass. Resection of an adrenal tumor and a liver tumor biopsy were performed. Twin 1 had no symptoms at 4 months of age. Screening by abdominal ultrasonography showed multiple masses in the liver but no adrenal mass. Metaiodobenzylguanidine scintigraphy showed positive findings in multiple liver masses. A laparoscopic biopsy for a liver tumor was performed. All primary tumor and liver tumor specimens from twin 2 and the liver tumor of twin 1 had the same histologic classification of neuroblastoma and nearly identical genetic aberrations, including a chromosome gain or loss using array-comparative genomic hybridization. From these clinical and pathologic findings and genetic analyses, we strongly demonstrate the transplacental metastatic spread from twin 2 to twin 1. In the literature, 9 pairs of concordant twin neuroblastomas, including the current twin, have been presented; and the clinical findings of 5 twin pairs may represent placental metastases from one twin with congenital neuroblastoma to the other twin. This study is the first report presenting the possibility of twin-to-twin metastasis in monozygotic twins with neuroblastoma based on an analysis of the clinical features and genetic aberrations.

Original languageEnglish
Pages (from-to)2312-2316
Number of pages5
JournalJournal of Pediatric Surgery
Issue number12
Publication statusPublished - Dec 2010

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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