Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010.

Kazuhiro Tobiishi; Shigeru Suzuki; Takashi Todaka; Hironori Hirakawa; Tsuguhide Hori; Jumboku Kajiwara; Teruaki Hirata; Takao Iida; Hiroshi Uchi; Masutaka Furue

Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010.

Kazuhiro Tobiishi, Shigeru Suzuki, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Jumboku Kajiwara, Teruaki Hirata, Takao Iida, Hiroshi Uchi, Masutaka Furue

Surgery

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Abstract

Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.

Original language	English
Pages (from-to)	136-142
Number of pages	7
Journal	Unknown Journal
Volume	104
Issue number	4
Publication status	Published - Apr 2013

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

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title = "Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010.",

abstract = "Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.",

author = "Kazuhiro Tobiishi and Shigeru Suzuki and Takashi Todaka and Hironori Hirakawa and Tsuguhide Hori and Jumboku Kajiwara and Teruaki Hirata and Takao Iida and Hiroshi Uchi and Masutaka Furue",

year = "2013",

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language = "English",

volume = "104",

pages = "136--142",

journal = "Unknown Journal",

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T1 - Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010.

AU - Tobiishi, Kazuhiro

AU - Suzuki, Shigeru

AU - Todaka, Takashi

AU - Hirakawa, Hironori

AU - Hori, Tsuguhide

AU - Kajiwara, Jumboku

AU - Hirata, Teruaki

AU - Iida, Takao

AU - Uchi, Hiroshi

AU - Furue, Masutaka

PY - 2013/4

Y1 - 2013/4

N2 - Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.

AB - Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.

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M3 - Article

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AN - SCOPUS:84886793443

SN - 1040-6182

VL - 104

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JO - Unknown Journal

JF - Unknown Journal

IS - 4

ER -

Concentration of hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of Yusho patients in 2010.

Abstract

All Science Journal Classification (ASJC) codes

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