TY - GEN
T1 - Computer support for physiological cell modelling using an ontology on cell physiology
AU - Shimayoshi, Takao
AU - Komurasaki, Kazuhiro
AU - Amano, Akira
AU - Iwashita, Takeshi
AU - Kanazawa, Masanori
AU - Matsuda, Tetsuya
PY - 2006
Y1 - 2006
N2 - The development of electrophyslological whole cell models to support the understanding of biological mechanisms Is Increasing rapidly. Due to the complexity of biological systems, comprehensive cell models, which are composed of many Imported sub-models of functional elements, can get quite complicated as well, making computer modification difficult. Here, we propose a computer support to enhance structural changes of cell models, employing the markup languages CellML and our original PMSML (Physiological Model Structure Markup Language), In addition to a new ontology for cell physiological modelling. In particular, a method to make references from CellML files to the ontology and a method to assist manipulation of model structures using markup languages together with the ontology are reported. Using these methods three software utilities, Including a graphical model editor, are Implemented. Experimental results proved that these methods are effective for the modification of electrophyslological models.
AB - The development of electrophyslological whole cell models to support the understanding of biological mechanisms Is Increasing rapidly. Due to the complexity of biological systems, comprehensive cell models, which are composed of many Imported sub-models of functional elements, can get quite complicated as well, making computer modification difficult. Here, we propose a computer support to enhance structural changes of cell models, employing the markup languages CellML and our original PMSML (Physiological Model Structure Markup Language), In addition to a new ontology for cell physiological modelling. In particular, a method to make references from CellML files to the ontology and a method to assist manipulation of model structures using markup languages together with the ontology are reported. Using these methods three software utilities, Including a graphical model editor, are Implemented. Experimental results proved that these methods are effective for the modification of electrophyslological models.
UR - http://www.scopus.com/inward/record.url?scp=34047155643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047155643&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.260282
DO - 10.1109/IEMBS.2006.260282
M3 - Conference contribution
AN - SCOPUS:34047155643
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 4171
EP - 4174
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -