Computed Tomography Features of Lung Adenocarcinomas With Programmed Death Ligand 1 Expression

Our objective was to clarify the computed tomography features of programmed death-ligand 1 (PD-L1)–expressing lung adenocarcinomas. Among 394 patients, 78 (19.8%) were positive for PD-L1 expression. On multivariate analysis, the presence of convergence (P <.01) and cavitation (P <.01) and the absence of surrounding ground glass opacity (P =.02) and air bronchogram (P =.03) were shown to be significantly associated with PD-L1 expression. Introduction The development of immune checkpoint inhibitors against programmed death 1 has paved the way for a new era of treatment of lung cancer. Programmed death-ligand 1 (PD-L1) is expected to predict the response of immune checkpoint inhibitors in lung cancer. Predicting PD-L1 expression using a noninvasive method before immunotherapy would, therefore, help identify patients for whom immunotherapy can be successful. Patients and Methods A total of 394 patients with resected lung adenocarcinoma who had undergone preoperative thin-section computed tomography (CT) were analyzed for PD-L1 expression by immunohistochemistry and evaluated to determine the association between PD-L1 expression and CT characteristics, including convergence, surrounding ground glass opacity (GGO), air bronchogram, notching, pleural indentation, spiculation, and cavitation. Results Of the 394 patients, 78 (19.8%) were positive and 316 (80.2%) were negative for PD-L1 expression. Univariate analysis demonstrated that PD-L1⁺ adenocarcinoma was significantly associated with the presence of convergence (P <.01), notching (P <.01), spiculation (P <.01), and cavitation (P <.01) and the absence of surrounding GGO (P <.01) compared with PD-L1⁻ cases. On multivariate analysis, the presence of convergence (P <.01) and cavitation (P <.01) and the absence of surrounding GGO (P =.02) and air bronchogram (P =.03) were significantly associated with PD-L1 expression. Conclusion PD-L1⁺ adenocarcinoma cases showed convergence and cavitation more frequently than did PD-L1⁻ cases. In contrast, surrounding GGO and air bronchogram were observed less frequently in PD-L1⁺ cases than in PD-L1⁻ cases. These results will prove helpful in identifying PD-L1–expressing adenocarcinoma by CT before immunotherapy.