Compositional Dependence of Bioactivity of Glasses in the System CaO-B2O3-SiO2: Its in vitro Evaluation

Chikara Ohtsuki, Yukio Kobayashi, Kanji Tsuru, Akiyoshi Osaka

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13 Citations (Scopus)


The essential condition for glasses and glass-ceramics to bond to living bone is the formation of a biologically active bone-like apatite layer on their surfaces in the body. In the present study, in order to investigate fundamentally the effect of B2O3on the bioactivity of glasses and glass-ceramics, the compositional dependence of apatite formation on the surface of glasses in the system CaO-B2O3-SiO2was examined in the simulated body fluid. Substitution of small amounts of B2O3for SiO2in CaO • SiO2 formula increased the rate of apatite formation on the surface of the glass, while substitution of more than 30 mol% B2O3for SiO2 decreased it. The substitution of B2O3for SiO2in CaO~SiO2 binary glasses accelerated the dissolution of Ca(II) ion from the glasses, and hence enhanced the increasing rate of degree of supersaturation of the surrounding fluid with respect to apatite. The decrease in the apatite forming ability by substitution of large amounts of B2O3for SiO2 is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.

Original languageEnglish
Pages (from-to)693-699
Number of pages7
JournalJournal of the Society of Materials Science, Japan
Issue number501
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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