Complex segregation analysis for two-locus model: Autosomal double recessive

Norikazu Yasuda, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


An autosomal doubly recessive mode of inheritance was implemented in segregation analysis, taken into account for segregation frequency, proportion of sporadic cases and ascertainment probability. Maximum likelihood scores are tabulated for some sizes of sibship. Segregation analysis thus becomes much easier with a desk calculator. The procedure has been illustrated for Graves disease.

Original languageEnglish
Pages (from-to)421-435
Number of pages15
JournalThe Japanese Journal of Human Genetics
Issue number4
Publication statusPublished - Dec 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)


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