TY - JOUR
T1 - Complete degradation of Yperite, a chemical warfare agent, by basidiomycetes
AU - Wariishi, Hiroyuki
AU - Itoh, Noriyuki
AU - Yoshida, Michiko
AU - Tanaka, Hiroo
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Scientific Research from the Japan Society for Promotion of Science and from the Kyushu University Interdisciplinary Program in Education and Projects in Research Development (to HW). IN was supported by Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists.
PY - 2002
Y1 - 2002
N2 - The complete degradation of Yperite (bis(2-chloroethyl) sulfide), a chemical warfare agent, was achieved by two basidiomycetous cultures. Two distinct metabolic pathways were detected in each fungus during degradation of Yperite. The major path involved a non-enzymatic hydrolysis to generate thiodiglycol. In the minor path, the sulfide bond was cleaved prior to the hydrolytic dechlorination reaction, yielding chloroethanol and chloromercaptoethane, both of which were then metabolized completely.
AB - The complete degradation of Yperite (bis(2-chloroethyl) sulfide), a chemical warfare agent, was achieved by two basidiomycetous cultures. Two distinct metabolic pathways were detected in each fungus during degradation of Yperite. The major path involved a non-enzymatic hydrolysis to generate thiodiglycol. In the minor path, the sulfide bond was cleaved prior to the hydrolytic dechlorination reaction, yielding chloroethanol and chloromercaptoethane, both of which were then metabolized completely.
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U2 - 10.1023/A:1014598524911
DO - 10.1023/A:1014598524911
M3 - Article
AN - SCOPUS:0036207788
SN - 0141-5492
VL - 24
SP - 501
EP - 505
JO - Biotechnology letters
JF - Biotechnology letters
IS - 6
ER -