Complement activation by polymers carrying hydroxyl groups

Yusuke Arima, Masako Kawagoe, Mitsuaki Toda, Hiroo Iwata

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Hydrogels of polymers carrying surface hydroxyl groups strongly activate the complement system through the alternative pathway, although it has also been reported that solutions of polymers do not. To address these curious, inconsistent results, we examined the effect of polymer states, either immobilized on a surface or soluble in serum, on the complement activation using a surface plasmon resonance apparatus and enzyme-linked immunosorbent assay. We clearly showed that dextran- and poly(vinyl alcohol)-immobilized surfaces strongly activated the complement system but that soluble polymers could not, even when the amounts of the soluble polymers added to serum were 4-2000 times higher than those on the polymer-immobilized surfaces.

Original languageEnglish
Pages (from-to)2400-2407
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number10
Publication statusPublished - Oct 28 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science


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