Compilation of copy number variants identified in phenotypically normal and parous Japanese women

Ohsuke Migita, Kayoko Maehara, Hiromi Kamura, Kei Miyakoshi, Mamoru Tanaka, Seiichi Morokuma, Kotaro Fukushima, Tomihiro Shimamoto, Shigeru Saito, Haruhiko Sago, Keiichiro Nishihama, Kosei Abe, Kazuhiko Nakabayashi, Akihiro Umezawa, Kohji Okamura, Kenichiro Hata

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


With increasing public concern about infertility and the frequent involvement of chromosomal anomalies in miscarriage, analyses of copy number variations (CNVs) have been used to identify the genomic regions responsible for each process of childbearing. Although associations between CNVs and diseases have been reported, many CNVs have also been identified in healthy individuals. Like other types of mutations, phenotypically indefinite CNVs may have been retained and accumulated during anthropogenesis. Therefore to distinguish causative variants from other variants is a formidable task. Furthermore, because previous studies have predominantly focused on European and African populations, comprehensive detection of common Asian CNVs is eagerly awaited. Here, using a high-resolution genotyping array and samples from 411 Japanese women with normal parity without significant complications, we have compiled 1043 copy number variable regions. In total, the collected regions cover 164 Mb, or up to 0.5% of the genome. The copy number differences in these regions may be irrelevant not only to infertility but also to a wide range of diseases. The utility of this resource in reducing the candidate pathogenetic variants, especially in Japanese subjects, is also demonstrated.

Original languageEnglish
Pages (from-to)326-331
Number of pages6
JournalJournal of Human Genetics
Issue number6
Publication statusPublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)


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