Comparison of the healing process in plated and non-plated fractures of the mandible in rats

L. Rasubala; H. Yoshikawa; A. A.S. Islam; K. Nagata; T. Iijima; M. Ohishi

doi:10.1016/j.bjoms.2004.02.020

Comparison of the healing process in plated and non-plated fractures of the mandible in rats

L. Rasubala, H. Yoshikawa, A. A.S. Islam, K. Nagata, T. Iijima, M. Ohishi

Maxillofacial Diagnostic & Surgical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

Original language	English
Pages (from-to)	315-322
Number of pages	8
Journal	British Journal of Oral and Maxillofacial Surgery
Volume	42
Issue number	4
DOIs	https://doi.org/10.1016/j.bjoms.2004.02.020
Publication status	Published - Aug 2004

All Science Journal Classification (ASJC) codes

Surgery
Oral Surgery
Otorhinolaryngology

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10.1016/j.bjoms.2004.02.020

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title = "Comparison of the healing process in plated and non-plated fractures of the mandible in rats",

abstract = "We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.",

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T1 - Comparison of the healing process in plated and non-plated fractures of the mandible in rats

AU - Rasubala, L.

AU - Yoshikawa, H.

AU - Islam, A. A.S.

AU - Nagata, K.

AU - Iijima, T.

AU - Ohishi, M.

PY - 2004/8

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AB - We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

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Comparison of the healing process in plated and non-plated fractures of the mandible in rats

Abstract

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