Comparison of the clinical courses of the opticospinal and conventional forms of multiple sclerosis in Japan

Manabu Osoegawa, Masaaki Niino, Masahito Tanaka, Seiji Kikuchi, Hiroyuki Murai, Toshiyuki Fukazawa, Motozumi Minohara, Ryuji Miyagishi, Takayuki Taniwaki, Kunio Tashiro, Jun Ichi Kira

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10 Citations (Scopus)


We evaluated the clinical courses of 216 patients with multiple sclerosis (MS) diagnosed according to the recommended diagnostic criteria of McDonald et al (10). Sixty-five patients clinically displaying selective involvement of the optic nerves and spinal cord were classified as opticospinal MS (OS-MS), while the other 151 showing disseminated involvement of the central nervous system were classified as conventional MS (C-MS). The disease duration did not differ significantly between the two sub-types (11.2 years vs. 11.5 years). In addition to a higher age of onset, female preponderance and higher Kurtzke's expanded disability status scale (EDSS) scores, the OSMS patients showed a markedly lower frequency of secondary progressive MS than the C-MS patients (4.6% vs. 29.1%, p=0.0001). The EDSS scores of the C-MS patients were significantly correlated with the disease duration, while those of the OS-MS patients were not. Among the C-MS patients, the frequency of secondary progressive MS was significantly more common in patients with a disease duration of more than 10 years than in those with a shorter duration. These results suggest that the irreversible disability in OS-MS is determined by relapses, rather than by chronic progression, whereas C-MS has a similar clinical course to MS in Westerners.

Original languageEnglish
Pages (from-to)934-938
Number of pages5
JournalInternal Medicine
Issue number9
Publication statusPublished - Oct 28 2005

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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