TY - JOUR
T1 - Comparison of prognostic scores in transplant-ineligible patients with peripheral T-cell lymphoma not otherwise specified and angioimmunoblastic T-cell lymphoma
T2 - a retrospective study from the national hospital organization in Japan
AU - Yamasaki, Satoshi
AU - Iida, Hiroatsu
AU - Yoshida, Isao
AU - Komeno, Takuya
AU - Sawamura, Morio
AU - Matsumoto, Morio
AU - Sekiguchi, Naoshiro
AU - Hishita, Terutoshi
AU - Sunami, Kazutaka
AU - Shimomura, Takeshi
AU - Takatsuki, Hiroshi
AU - Yoshida, Shinichiro
AU - Otsuka, Maki
AU - Kato, Takeharu
AU - Kuroda, Yoshiaki
AU - Ooyama, Tadashi
AU - Suzuki, Yasuhiro
AU - Ohshima, Koichi
AU - Nagai, Hirokazu
AU - Iwasaki, Hiromi
N1 - Funding Information:
The article processing charges were funded by the authors. We thank the patients and clinical staff for their participation in the study. We also thank the doctors in the 12 hospitals for checking the medical records. The authors also acknowledge the Clinical Research Institute, Kyushu Medical Hospital for editorial support. The article processing charges were funded by the authors. We thank Susan Furness, PhD, and Gillian Campbell, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - We retrospectively analyzed the risk factors for outcomes among patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS, n = 100) and angioimmunoblastic T-cell lymphoma (AITL, n = 128) who did not receive hematopoietic stem cell transplantation between 2008 and 2018. We designed a comparison of prognostic scores specifically for PTCL-NOS and AITL. The international prognostic index (IPI) was useful for investigating the risk factors associated with outcomes among transplant-ineligible patients with PTCL-NOS (Harrell’s c-statistic 0.715) and AITL (c-statistic 0.615). The prognostic index for T-cell lymphoma (PIT), modified PIT, and the International Peripheral T Cell Lymphoma Project for overall survival (OS) seemed to identify separate prognostic groups, based on visual assessment of Kaplan–Meier curves. However, better c-statistics (>0.7) were only found for the IPI score for OS in PTCL-NOS. Strategies that carefully select PTCL patients with higher IPI scores may help to identify individuals suitable for novel therapies.
AB - We retrospectively analyzed the risk factors for outcomes among patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS, n = 100) and angioimmunoblastic T-cell lymphoma (AITL, n = 128) who did not receive hematopoietic stem cell transplantation between 2008 and 2018. We designed a comparison of prognostic scores specifically for PTCL-NOS and AITL. The international prognostic index (IPI) was useful for investigating the risk factors associated with outcomes among transplant-ineligible patients with PTCL-NOS (Harrell’s c-statistic 0.715) and AITL (c-statistic 0.615). The prognostic index for T-cell lymphoma (PIT), modified PIT, and the International Peripheral T Cell Lymphoma Project for overall survival (OS) seemed to identify separate prognostic groups, based on visual assessment of Kaplan–Meier curves. However, better c-statistics (>0.7) were only found for the IPI score for OS in PTCL-NOS. Strategies that carefully select PTCL patients with higher IPI scores may help to identify individuals suitable for novel therapies.
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U2 - 10.1080/10428194.2020.1845336
DO - 10.1080/10428194.2020.1845336
M3 - Article
C2 - 33167741
AN - SCOPUS:85095742902
SN - 1042-8194
VL - 62
SP - 819
EP - 827
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -
