TY - JOUR
T1 - Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer
AU - Shiomi, Miho
AU - Mori, Shinichiro
AU - Shinoto, Makoto
AU - Nakayama, Yuko
AU - Kamada, Tadashi
AU - Yamada, Shigeru
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Purpose To compare carbon-ion beam dose distribution between passive and scanning radiation therapies for locally advanced pancreatic cancer. Materials and methods Thirteen pancreatic cancer patients were included in this study. Four types of treatment planning with respiratory gating were calculated for each patient: a four-field box with passive irradiation (Plan 1), scanning irradiation (Plan 2), a three-field (150°, 180° and 210°) protocol with passive irradiation (Plan 3), and scanning irradiation (Plan 4). The irradiation plans each delivered 55.2 Gy (RBE) to the planning target volume (PTV) and were compared with respect to doses to the PTV and organs at risk (OARs). Results Plan 3 exceeded the dose assessment metrics to the spinal cord. Scanning irradiation plans (Plan 2 and, particularly, Plan 4) offered significantly reduced dosage to the stomach and the duodenum compared with passive irradiation. Conclusion Three-field oblique scanning irradiation for pancreatic cancer has the potential to reduce gastrointestinal exposure and influence of peristalsis on dose distribution.
AB - Purpose To compare carbon-ion beam dose distribution between passive and scanning radiation therapies for locally advanced pancreatic cancer. Materials and methods Thirteen pancreatic cancer patients were included in this study. Four types of treatment planning with respiratory gating were calculated for each patient: a four-field box with passive irradiation (Plan 1), scanning irradiation (Plan 2), a three-field (150°, 180° and 210°) protocol with passive irradiation (Plan 3), and scanning irradiation (Plan 4). The irradiation plans each delivered 55.2 Gy (RBE) to the planning target volume (PTV) and were compared with respect to doses to the PTV and organs at risk (OARs). Results Plan 3 exceeded the dose assessment metrics to the spinal cord. Scanning irradiation plans (Plan 2 and, particularly, Plan 4) offered significantly reduced dosage to the stomach and the duodenum compared with passive irradiation. Conclusion Three-field oblique scanning irradiation for pancreatic cancer has the potential to reduce gastrointestinal exposure and influence of peristalsis on dose distribution.
UR - http://www.scopus.com/inward/record.url?scp=84973639316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973639316&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2016.04.026
DO - 10.1016/j.radonc.2016.04.026
M3 - Article
C2 - 27262617
AN - SCOPUS:84973639316
SN - 0167-8140
VL - 119
SP - 326
EP - 330
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 2
ER -
