TY - JOUR
T1 - Comparison of bleeding risks related to venous thromboembolism prophylaxis in laparoscopic vs open colorectal cancer surgery
T2 - a multicenter study in Japanese patients
AU - Yasui, Masayoshi
AU - Ikeda, Masataka
AU - Miyake, Masakazu
AU - Ide, Yoshihito
AU - Okuyama, Masaki
AU - Shingai, Tatsushi
AU - Kitani, Kotaro
AU - Ikenaga, Masakazu
AU - Hasegawa, Junichi
AU - Akamatsu, Hiroki
AU - Murata, Kohei
AU - Takemasa, Ichiro
AU - Mizushima, Tsunekazu
AU - Yamamoto, Hirofumi
AU - Sekimoto, Mitsugu
AU - Nezu, Riichiro
AU - Doki, Yuichiro
AU - Mori, Masaki
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background Venous thromboembolism is the most common preventable cause of hospital death. The objective of this study was to clarify risk factors for postoperative bleeding related to thromboprophylaxis after laparoscopic colorectal cancer surgery. Methods The study was conducted at 23 Japanese institutions and included patients with colorectal cancer who underwent laparoscopic or open surgery followed by fondaparinux treatment. We performed a retrospective analysis from a prospectively maintained database. We used multivariate analyses to evaluate clinical risk factors for prophylaxis-related bleeding events. Results After multivariate analysis, male gender, intraoperative blood loss of less than 25 mL, and a preoperative platelet count below 15 × 104/μL were found to be independent risk factors in the laparoscopic surgery group. Only the preoperative platelet count was an independent risk factor in the open surgery group. Conclusions Different prophylactic treatments for postoperative venous thromboembolism may be necessary in laparoscopic vs open surgery for colorectal cancer.
AB - Background Venous thromboembolism is the most common preventable cause of hospital death. The objective of this study was to clarify risk factors for postoperative bleeding related to thromboprophylaxis after laparoscopic colorectal cancer surgery. Methods The study was conducted at 23 Japanese institutions and included patients with colorectal cancer who underwent laparoscopic or open surgery followed by fondaparinux treatment. We performed a retrospective analysis from a prospectively maintained database. We used multivariate analyses to evaluate clinical risk factors for prophylaxis-related bleeding events. Results After multivariate analysis, male gender, intraoperative blood loss of less than 25 mL, and a preoperative platelet count below 15 × 104/μL were found to be independent risk factors in the laparoscopic surgery group. Only the preoperative platelet count was an independent risk factor in the open surgery group. Conclusions Different prophylactic treatments for postoperative venous thromboembolism may be necessary in laparoscopic vs open surgery for colorectal cancer.
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U2 - 10.1016/j.amjsurg.2015.10.019
DO - 10.1016/j.amjsurg.2015.10.019
M3 - Article
C2 - 26772140
AN - SCOPUS:84954270990
SN - 0002-9610
VL - 213
SP - 43
EP - 49
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 1
ER -
