Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus

Noriko Tsuchimochi; Yujiro Uchida; Yoji Nagasaki; Yoshihiro Eriguchi; Yoriko Maehara; Masako Kadowaki; Nobuyuki Shimono

Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus

Noriko Tsuchimochi
, Yujiro Uchida
, Yoji Nagasaki
, Yoshihiro Eriguchi
, Yoriko Maehara
, Masako Kadowaki
, Nobuyuki Shimono

Research output: Contribution to journal › Article › peer-review

Abstract

In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7%) and 159 strains (76.8%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Japanese Journal of Chemotherapy
Volume	55
Issue number	5
Publication status	Published - Sept 2007

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)

Cite this

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title = "Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus",

abstract = "In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7\%) and 159 strains (76.8\%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6\%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.",

author = "Noriko Tsuchimochi and Yujiro Uchida and Yoji Nagasaki and Yoshihiro Eriguchi and Yoriko Maehara and Masako Kadowaki and Nobuyuki Shimono",

year = "2007",

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language = "English",

volume = "55",

pages = "363--367",

journal = "Japanese Journal of Chemotherapy",

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T1 - Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus

AU - Tsuchimochi, Noriko

AU - Uchida, Yujiro

AU - Nagasaki, Yoji

AU - Eriguchi, Yoshihiro

AU - Maehara, Yoriko

AU - Kadowaki, Masako

AU - Shimono, Nobuyuki

PY - 2007/9

Y1 - 2007/9

N2 - In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7%) and 159 strains (76.8%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.

AB - In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7%) and 159 strains (76.8%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.

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UR - https://www.scopus.com/pages/publications/34948853322#tab=citedBy

M3 - Article

AN - SCOPUS:34948853322

SN - 1340-7007

VL - 55

SP - 363

EP - 367

JO - Japanese Journal of Chemotherapy

JF - Japanese Journal of Chemotherapy

IS - 5

ER -

Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus

Abstract

All Science Journal Classification (ASJC) codes

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