Combination therapy of resection and intraoperative radiation for patients with carcinomas of extrahepatic bile duct and ampulla of Vater: Prognostic advantage over resection alone?

Kenji Nakano, Kazuo Chijiiwa, Takayuki Toyonaga, Junji Ueda, Yuji Takamatsu, Masahiko Kimura, Katsumasa Nakamura, Koji Yamaguchi, Masao Tanaka

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background/Aims: To investigate the therapeutic efficacy of intraoperative radiation for carcinomas of the bile duct and ampulla of Vater. Methodology: Postoperative morbidity, mortality and survival of patients undergoing surgical resection of ampullary cancer (n=19) and bile duct cancer (n=28) were retrospectively compared between two groups with and without intraoperative radiation. Results: Background items (age, gender, preoperative laboratory data, operative time and bleeding volume, tumor stage) did not differ significantly between the two groups. The predominant postoperative complication was leakage of pancreatic juice, which occurred in similar rates in both groups. No significant differences were noted in the 3-year survival rates between the resection plus intraoperative radiation group and resection alone group (60.0% (n=5) vs. 50.1% (n=13) for ampullary cancer; 0% (n=4) vs. 27.1% (n=24) for bile duct cancer, respectively). The main causes of recurrence were distant metastasis for ampullary cancer and microscopic residue of carcinoma for bile duct cancer. Conclusions: The combination of intraoperative radiation and resection may add no significant benefit to patients with ampullary and bile duct cancer when compared with resection alone.

Original languageEnglish
Pages (from-to)928-933
Number of pages6
JournalHepato-gastroenterology
Volume50
Issue number52
Publication statusPublished - Jul 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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