TY - JOUR
T1 - Colorectal polypectomy and risk of colorectal cancer by subsite
T2 - The Fukuoka colorectal cancer study
AU - Yoshida, Daigo
AU - Kono, Suminori
AU - Moore, Malcolm A.
AU - Toyomura, Kengo
AU - Nagano, Jun
AU - Mizoue, Tetsuya
AU - Mibu, Ryuichi
AU - Tanaka, Masao
AU - Kakeji, Yoshihiro
AU - Maehara, Yoshihiko
AU - Okamura, Takeshi
AU - Ikejiri, Koji
AU - Futami, Kitaroh
AU - Yasunami, Yohichi
AU - Maekawa, Takafumi
AU - Takenaka, Kenji
AU - Ichimiya, Hitoshi
AU - Imaizumi, Nobutoshi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (12218226) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors acknowledge support from Emeritus Professor Keizo Sugimachi, Professors Seiyo Ikeda, Takayuki Shirakusa and Sumitaka Arima, and Drs Motonori Saku, Yoichi Ikeda, Soichiro Maekawa, Kazuo Tanoue, Kinjiro Sumiyoshi and Shoichiro Saito in conducting the survey of cases. The following physicians kindly supervised the survey of controls at their clinics: Drs Hideaki Baba, Tomonori Endo, Hiroshi Hara, Yoichiro Hirokata, Motohisa Ikeda, Masayoshi Ishibashi, Fumiaki Itoh, Yasuhiro Iwanaga, Hideki Kaku, Shoshi Kaku, Minoru Kanazawa, Akira Kobayashi, Ryunosuke Kumashiro, Shinichi Matsumoto, Soukei Mioka, Umeji Miyakoda, Osamu Nakagaki, Nobuyoshi Nogawa, Nobuyuki Ogami, Toyoaki Okabayashi, Hironao Okabe, Nishiki Saku, Masafumi Tanaka, Masahiro Ueda, Bunichi Ushio and Koheisho Yasunaga. The authors are grateful to research nurses: Ms Nobuko Taguchi, Yuriko Moroe, Yuko Noda, Ryoko Tanaka, Hisako Nakagawa and Yoko Mikasa, and research clerk Ms Hiroko Mizuta, for their self-sacrificing work.
PY - 2007/8
Y1 - 2007/8
N2 - Background: Colorectal adenomas are well-established precursor lesions for colorectal cancer and removal of polyps is deemed to reduce the risk of colorectal cancer. However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study. Methods: Both case patients and control subjects were residents aged 20-74 years in Fukuoka City and three adjacent areas. The case group comprised 840 patients undergoing surgery for a first diagnosis of colorectal cancer, while the control subjects were 833 residents who were selected in the community by two-stage random sampling. Past history of selected diseases, surgery and lifestyle factors were ascertained by in-person interview. Statistical adjustment was made for sex, 5-year age class, residence, smoking, alcohol drinking, physical activity, body mass index and parental history of colorectal cancer. Results: Overall, 74 case patients (9%) and 85 control subjects (10%) reported a prior history of colorectal polyps, and 50 cases (6%) and 64 controls (8%) had a history of colorectal polypectomy. The adjusted odds ratio associated with colorectal polypectomy was 0.71 (95% confidence interval [CI] 0.48-1.06) for the overall risk of colorectal cancer. The corresponding values for cancer of the proximal colon, distal colon, and rectum were 1.68 (95% CI 0.98-2.88), 0.71 (95% CI 0.41-1.26) and 0.24 (95% CI 0.11-0.52), respectively. Conclusions: The findings indicate that colorectal polypectomy in current practice confers a decreased risk of rectal cancer and possibly of distal colon cancer.
AB - Background: Colorectal adenomas are well-established precursor lesions for colorectal cancer and removal of polyps is deemed to reduce the risk of colorectal cancer. However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study. Methods: Both case patients and control subjects were residents aged 20-74 years in Fukuoka City and three adjacent areas. The case group comprised 840 patients undergoing surgery for a first diagnosis of colorectal cancer, while the control subjects were 833 residents who were selected in the community by two-stage random sampling. Past history of selected diseases, surgery and lifestyle factors were ascertained by in-person interview. Statistical adjustment was made for sex, 5-year age class, residence, smoking, alcohol drinking, physical activity, body mass index and parental history of colorectal cancer. Results: Overall, 74 case patients (9%) and 85 control subjects (10%) reported a prior history of colorectal polyps, and 50 cases (6%) and 64 controls (8%) had a history of colorectal polypectomy. The adjusted odds ratio associated with colorectal polypectomy was 0.71 (95% confidence interval [CI] 0.48-1.06) for the overall risk of colorectal cancer. The corresponding values for cancer of the proximal colon, distal colon, and rectum were 1.68 (95% CI 0.98-2.88), 0.71 (95% CI 0.41-1.26) and 0.24 (95% CI 0.11-0.52), respectively. Conclusions: The findings indicate that colorectal polypectomy in current practice confers a decreased risk of rectal cancer and possibly of distal colon cancer.
UR - http://www.scopus.com/inward/record.url?scp=44849124197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44849124197&partnerID=8YFLogxK
U2 - 10.1093/jjco/hym065
DO - 10.1093/jjco/hym065
M3 - Article
C2 - 17716994
AN - SCOPUS:44849124197
SN - 0368-2811
VL - 37
SP - 597
EP - 602
JO - Japanese journal of clinical oncology
JF - Japanese journal of clinical oncology
IS - 8
ER -
