TY - JOUR
T1 - Color reaction of 3,4-methylenedioxyamphetamines with chromotropic acid
T2 - Its improvement and application to the screening of seized tablets
AU - Matsuda, Kumi
AU - Fukuzawa, Tomoko
AU - Ishii, Yuji
AU - Yamada, Hideyuki
N1 - Funding Information:
Acknowledgments This work was supported by a Health Science Research Grant from the Ministry of Health, Labour, and Welfare, Japan.
PY - 2007/6
Y1 - 2007/6
N2 - We have previously reported basic data on the specificity of the color reaction of 3,4-methylenedioxymethamphetamine (MDMA) and related drugs with chromotropic acid (CTA) and sulfuric acid. In this communication, we report an extended line of experiments that optimized reaction conditions, and we describe the application of this method to screening for MDMA or 3,4- methylendioxyamphetamine (MDA) in seized tablets. The optimal concentration of CTA and optimal reaction time at room temperature were 1.0 mM and 30 min, respectively. Final concentrations of MDMA of less than 100 μM should be used to avoid nonspecific color development. The CTA-dependent color reaction was also studied using aqueous extracts from seized tablets containing MDMA or MDA. On the basis of our results, we conclude that the present procedure is useful for screening for MDMA and MDA in seized tablets.
AB - We have previously reported basic data on the specificity of the color reaction of 3,4-methylenedioxymethamphetamine (MDMA) and related drugs with chromotropic acid (CTA) and sulfuric acid. In this communication, we report an extended line of experiments that optimized reaction conditions, and we describe the application of this method to screening for MDMA or 3,4- methylendioxyamphetamine (MDA) in seized tablets. The optimal concentration of CTA and optimal reaction time at room temperature were 1.0 mM and 30 min, respectively. Final concentrations of MDMA of less than 100 μM should be used to avoid nonspecific color development. The CTA-dependent color reaction was also studied using aqueous extracts from seized tablets containing MDMA or MDA. On the basis of our results, we conclude that the present procedure is useful for screening for MDMA and MDA in seized tablets.
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U2 - 10.1007/s11419-007-0022-x
DO - 10.1007/s11419-007-0022-x
M3 - Article
AN - SCOPUS:34249780386
SN - 1860-8965
VL - 25
SP - 37
EP - 40
JO - Forensic Toxicology
JF - Forensic Toxicology
IS - 1
ER -