Coffee and green tea consumption is associated with insulin resistance in japanese adults

Ngoc Minh Pham, Akiko Nanri, Takeshi Kochi, Keisuke Kuwahara, Hiroko Tsuruoka, Kayo Kurotani, Shamima Akter, Isamu Kabe, Masao Sato, Hitomi Hayabuchi, Tetsuya Mizoue

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Objective Higher coffee and green tea consumption has been suggested to decrease risk of type 2 diabetes, but their roles in insulin resistance (IR) and insulin secretion remain unclear. This study examined the association between habitual consumption of these beverages and markers of glucose metabolism in a Japanese working population. Materials/Methods Participants were 1440 Japanese employees (1151 men and 289 women) aged 18-69 years. Consumption of coffee and green tea was ascertained via a validated brief diet history questionnaire. Multilevel linear regression was used to estimate means (95% confidence intervals) of fasting insulin, fasting plasma glucose, homeostatic model assessment of IR (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β) and glycated hemoglobin (HbA1c) with adjustment for potential confounding variables. Results Coffee consumption was significantly, inversely associated with HOMA-IR (P for trend = 0.03), and the association appeared to be confined to overweight subjects (BMI ≥ 25 kg/m2) (P for trend = 0.01, P for interaction = 0.08). Unexpectedly, green tea consumption was positively associated with HOMA-IR (P for trend = 0.02), though there was no dose-response relationship among daily consumers of green tea. Neither coffee nor green tea consumption was associated with HOMA-β and HbA1c. Conclusions Our findings indicate that coffee consumption may be associated with decreased IR, but not with insulin secretion. The positive association between green tea consumption and IR warrants further investigation.

Original languageEnglish
Pages (from-to)400-408
Number of pages9
JournalMetabolism: Clinical and Experimental
Issue number3
Publication statusPublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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