Cocaine-Induced Coronary-Artery Constriction

John J. Ambre, R. Douglas Wilkerson, Theodore D. Fraker, Peter N. Temesy-Armos, Kensuke Egashira, James P. Morgan, Louis L. Cregler, Anthony E. Folev, Richard A. Lange, Ricardo G. Cigarroa, L. David Hillis

Research output: Contribution to journalLetterpeer-review

4 Citations (Scopus)


To the Editor: The conclusion of Lange et al. (Dec. 7 issue)1 from their study of cocaine-induced coronary-artery constriction implies that they know the shape of the cocaine dose–response curve for cardiac effects. They used doses of 110 to 210 mg intranasally (which are only about 30 percent bioavailable2) and produced cocaine concentrations of 30 to 220 ng per milliliter. We have acquired noninvasive and clinical cardiac data in 30 studies of intravenous cocaine users at plasma cocaine concentrations in the range produced by recreational use. In addition to five subjects receiving 30 mg of cocaine by intravenous injection,.

Original languageEnglish
Pages (from-to)1235-1237
Number of pages3
JournalNew England Journal of Medicine
Issue number17
Publication statusPublished - Apr 26 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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