Close link between development and function of gamma-delta T cells

Kensuke Shibata

    Research output: Contribution to journalReview articlepeer-review

    15 Citations (Scopus)


    Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.

    Original languageEnglish
    Pages (from-to)217-227
    Number of pages11
    Issue number4
    Publication statusPublished - Apr 2012

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Virology


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