Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yasunobu Yoshikai, Hiroyuki Kidokoro, Keiko Kimura, Yoshiyasu Aoki, Masahiko Makino, Kenji Hiromatsu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

Original languageEnglish
Pages (from-to)746-749
Number of pages4
JournalJournal of virology
Volume71
Issue number1
DOIs
Publication statusPublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Fingerprint

Dive into the research topics of 'Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS'. Together they form a unique fingerprint.

Cite this