TY - JOUR
T1 - Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma
T2 - A multi-institutional study of the Japan pancreas society
AU - Yamao, Kenji
AU - Yanagisawa, Akio
AU - Takahashi, Kuniyuki
AU - Kimura, Wataru
AU - Doi, Ryuichiro
AU - Fukushima, Noriyoshi
AU - Ohike, Nobuyuki
AU - Shimizu, Michio
AU - Hatori, Takashi
AU - Nobukawa, Bunsei
AU - Hifumi, Michio
AU - Kobayashi, Yuji
AU - Tobita, Kosuke
AU - Tanno, Satoshi
AU - Sugiyama, Masanori
AU - Miyasaka, Yoshihiro
AU - Nakagohri, Toshio
AU - Yamaguchi, Taketo
AU - Hanada, Keiji
AU - Abe, Hideki
AU - Tada, Minoru
AU - Fujita, Naotaka
AU - Tanaka, Masao
PY - 2011/1
Y1 - 2011/1
N2 - Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). MATERIALS AND Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. RESULT: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7%) and 21 noninvasive (13.4%) and 6 invasive carcinomas (3.9%). Patients with MCN were exclusively women (98.1%) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1%. The 3-, 5-, and 10-year survival rates were 97.6%, 96.6%, and 96.6%, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.
AB - Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). MATERIALS AND Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. RESULT: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7%) and 21 noninvasive (13.4%) and 6 invasive carcinomas (3.9%). Patients with MCN were exclusively women (98.1%) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1%. The 3-, 5-, and 10-year survival rates were 97.6%, 96.6%, and 96.6%, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.
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U2 - 10.1097/MPA.0b013e3181f749d3
DO - 10.1097/MPA.0b013e3181f749d3
M3 - Article
C2 - 20924309
AN - SCOPUS:78650960917
SN - 0885-3177
VL - 40
SP - 67
EP - 71
JO - Pancreas
JF - Pancreas
IS - 1
ER -
