Clinicopathological characteristics of intraductal papillary neoplasm of the bile duct: a Japan-Korea collaborative study

Keiichi Kubota, Jin Young Jang, Yasuni Nakanuma, Kee Taek Jang, Yasuo Haruyama, Noriyoshi Fukushima, Toru Furukawa, Seung Mo Hong, Yuhki Sakuraoka, Haeryoung Kim, Takatsugu Matsumoto, Kyung Bun Lee, Yoh Zen, Jaeri Kim, Masaru Miyazaki, Dong Wook Choi, Jin Seok Heo, Itaru Endo, Shin Hwang, Masafumi NakamuraHo Seong Han, Shinji Uemoto, Sang Jae Park, Eun Kyung Hong, Atsushi Nanashima, Dong Sik Kim, Joo Young Kim, Tetsuo Ohta, Koo Jeong Kang, Takumi Fukumoto, Yang Won Nah, Hyung Il Seo, Kazuo Inui, Dong Sup Yoon, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Background: The prevalent location and incidence of intraductal papillary neoplasm of the bile duct (IPNB) and invasive carcinoma associated with them have varied markedly among studies due to differences in diagnostic criteria and tumor location. Methods: IPNBs were classified into two types: Type 1 IPNB, being histologically similar to intraductal papillary mucinous neoplasm of the pancreas, and Type 2 IPNB, having a more complex histological architecture with irregular papillary branching or foci of solid-tubular components. Medical data were evaluated. Results: Among 694 IPNB patients, 520 and 174 had Type 1 and Type 2, respectively. The levels of AST, ALT, ALP, T. Bil, and CEA were significantly higher in patients with Type 2 than in those with Type 1. Type 1 IPNB was more frequently located in the intrahepatic bile duct than Type 2, whereas Type 2 was more frequently located in the distal bile duct than Type 1 IPNB (P ' 0.001). There were significant differences in 5-year cumulative survival rates (75.2% vs 50.9%; P ' 0.0001) and 5-year cumulative disease-free survival rates (64.1% vs 35.3%; P ' 0.0001) between the two groups. Conclusion: Type 1 and Type 2 IPNBs differ in their clinicopathological features and prognosis. This classification may help to further understand IPNB.

Original languageEnglish
Pages (from-to)581-597
Number of pages17
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Issue number9
Publication statusPublished - Sept 1 2020

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology


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