Clinicopathological Characteristics of Esophageal Squamous Cell Carcinoma in Patients Younger Than 50 years

Yuta Kasagi; Masaru Morita; Hajime Otsu; Hiroyuki Kawano; Koji Ando; Yukiharu Hiyoshi; Shuhei Ito; Yuji Miyamoto; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara

doi:10.1245/s10434-014-3856-6

Clinicopathological Characteristics of Esophageal Squamous Cell Carcinoma in Patients Younger Than 50 years

Yuta Kasagi, Masaru Morita, Hajime Otsu, Hiroyuki Kawano, Koji Ando, Yukiharu Hiyoshi, Shuhei Ito, Yuji Miyamoto, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Purpose: This study clarifies age differences in clinicopathologic characteristics and risk factor exposure of patients who have undergone esophagectomy for esophageal cancer (EC).

Methods: Clinical results of esophagectomy were compared between 22 patients younger than 50years of age (Group I) and 327 patients older than 50 years of age (Group II) with esophageal squamous cell carcinoma.

Results: The two groups did not significantly differ in clinicopathological characteristics, including prognosis. Postoperative pulmonary complication incidence rates were 4.2% (Group I) and 14.4% (Group II). In Group I, the incidence of multiple ECs was 36.4%, and association with head and neck cancer was 31.8%, which were significantly higher than in Group II (13.4%, p=0.021; and 9.2%, p=0.015, respectively). Furthermore, the patients in Group I with multiple cancers were almost all heavy smokers and/or users of alcohol.

Conclusions: These results suggest that multiple upper aerodigestive tract cancers are associated with heavy exposure to risk factors in patients younger than 50years of age.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Annals of Surgical Oncology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1245/s10434-014-3856-6
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1245/s10434-014-3856-6

Cite this

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title = "Clinicopathological Characteristics of Esophageal Squamous Cell Carcinoma in Patients Younger Than 50 years",

abstract = "Purpose: This study clarifies age differences in clinicopathologic characteristics and risk factor exposure of patients who have undergone esophagectomy for esophageal cancer (EC).Methods: Clinical results of esophagectomy were compared between 22 patients younger than 50years of age (Group I) and 327 patients older than 50 years of age (Group II) with esophageal squamous cell carcinoma.Results: The two groups did not significantly differ in clinicopathological characteristics, including prognosis. Postoperative pulmonary complication incidence rates were 4.2% (Group I) and 14.4% (Group II). In Group I, the incidence of multiple ECs was 36.4%, and association with head and neck cancer was 31.8%, which were significantly higher than in Group II (13.4%, p=0.021; and 9.2%, p=0.015, respectively). Furthermore, the patients in Group I with multiple cancers were almost all heavy smokers and/or users of alcohol.Conclusions: These results suggest that multiple upper aerodigestive tract cancers are associated with heavy exposure to risk factors in patients younger than 50years of age.",

author = "Yuta Kasagi and Masaru Morita and Hajime Otsu and Hiroyuki Kawano and Koji Ando and Yukiharu Hiyoshi and Shuhei Ito and Yuji Miyamoto and Hiroshi Saeki and Eiji Oki and Yoshihiko Maehara",

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doi = "10.1245/s10434-014-3856-6",

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TY - JOUR

T1 - Clinicopathological Characteristics of Esophageal Squamous Cell Carcinoma in Patients Younger Than 50 years

AU - Kasagi, Yuta

AU - Morita, Masaru

AU - Otsu, Hajime

AU - Kawano, Hiroyuki

AU - Ando, Koji

AU - Hiyoshi, Yukiharu

AU - Ito, Shuhei

AU - Miyamoto, Yuji

AU - Saeki, Hiroshi

AU - Oki, Eiji

AU - Maehara, Yoshihiko

PY - 2015

Y1 - 2015

N2 - Purpose: This study clarifies age differences in clinicopathologic characteristics and risk factor exposure of patients who have undergone esophagectomy for esophageal cancer (EC).Methods: Clinical results of esophagectomy were compared between 22 patients younger than 50years of age (Group I) and 327 patients older than 50 years of age (Group II) with esophageal squamous cell carcinoma.Results: The two groups did not significantly differ in clinicopathological characteristics, including prognosis. Postoperative pulmonary complication incidence rates were 4.2% (Group I) and 14.4% (Group II). In Group I, the incidence of multiple ECs was 36.4%, and association with head and neck cancer was 31.8%, which were significantly higher than in Group II (13.4%, p=0.021; and 9.2%, p=0.015, respectively). Furthermore, the patients in Group I with multiple cancers were almost all heavy smokers and/or users of alcohol.Conclusions: These results suggest that multiple upper aerodigestive tract cancers are associated with heavy exposure to risk factors in patients younger than 50years of age.

AB - Purpose: This study clarifies age differences in clinicopathologic characteristics and risk factor exposure of patients who have undergone esophagectomy for esophageal cancer (EC).Methods: Clinical results of esophagectomy were compared between 22 patients younger than 50years of age (Group I) and 327 patients older than 50 years of age (Group II) with esophageal squamous cell carcinoma.Results: The two groups did not significantly differ in clinicopathological characteristics, including prognosis. Postoperative pulmonary complication incidence rates were 4.2% (Group I) and 14.4% (Group II). In Group I, the incidence of multiple ECs was 36.4%, and association with head and neck cancer was 31.8%, which were significantly higher than in Group II (13.4%, p=0.021; and 9.2%, p=0.015, respectively). Furthermore, the patients in Group I with multiple cancers were almost all heavy smokers and/or users of alcohol.Conclusions: These results suggest that multiple upper aerodigestive tract cancers are associated with heavy exposure to risk factors in patients younger than 50years of age.

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