Clinical study of squamous cell carcinoma of the thyroid gland

Takeichiro Aso, Hideyuki Kiyohara, Mioko Matsuo, Fumihide Rikimaru, Junichi Fukushima, Yuichiro Higaki, Muneyuki Masuda

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Squamous cell carcinoma of the thyroid gland is a rare disease. Although several mechanisms have been proposed, the pathogenesis of the disease is not known. A majority of cases are at an advanced stage at the time of diagnosis and the clinical course is extremely aggressive. This is because the tumor often invades directly into neighboring organs, metastasizes, and is refractory to conventional treatments. As a result, a clinically effective therapy is not established for this biologically aggressive tumor with extremely poor prognosis. From January 2000 to December 2012, there were three cases of squamous cell carcinoma of the thyroid gland, accounting for 1.1% of all thyroid cancers treated in our department. Two patients who were treated with radical surgery plus chemoradiotherapy developed distant metastases. One of them died at 20 months after the initial treatment, while the other remained alive with metastatic tumor for 44 months. One inoperable patient died 5 months after CRT. For operable cases, multimodality treatment with radical surgery may be preferable, leading to longer survival.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJapanese Journal of Head and Neck Cancer
Issue number1
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Oncology


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