Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer

J. Kinoshita, K. Kitamura, A. Kabashima, H. Saeki, S. Tanaka, K. Sugimachi

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140 Citations (Scopus)


Vascular endothelial growth factor-C (VEGF-C) is a specific ligand which induces lymphangiogenesis. We examined the expression of VEGF-C protein to determine its role in the progression of breast cancer. Immunohistochemical analysis revealed that VEGF-C was overexpressed in 39 of 98 breast cancer specimens (39.8%) but not in adjacent normal mammary glands. The expression of VEGF-C showed a significant correlation with lymphatic vessel invasion (p = 0.0004). It is noteworthy that the 5-year disease free survival rate of the VEGF-C positive group was significantly poorer than that of negative group (p = 0.0356). We suggest that as expression of VEGF-C is not implicated in lymphatic spread, it may prove to be a promising marker to predict the recurrence of breast cancer.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalBreast Cancer Research and Treatment
Issue number2
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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