Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma

K. Mimori, M. Mori, T. Shiraishi, T. Fujie, K. Baba, M. Haraguchi, R. Abe, H. Ueo, T. Akiyoshi

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100 Citations (Scopus)


Tissue inhibitor of metalloproteinase (TIMP) has been reported to inhibit tumour invasion through an inactivation of matrix metalloproteinase (MMP) both in vitro and in vivo. Among the TIMP family, TIMP-I possesses not only proteinase inhibitory activity but also a growth-promoting function. However, the significance of the expression of TIMP-1 in human gastric carcinoma tissue has yet to be clarified. In 50 examined cases of gastric carcinoma, 44 (88%) cases showed a higher expression of TIMP-1 mRNA in the biopsy samples from the tumour tissue (T) than in the biopsy samples from the corresponding normal tissue (N), as determined by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR). In a multivariate analysis, the TIN ratio of TIMP-1 mRNA was found to be an independent factor influencing the depth of tumour invasion and was the second most important factor in determining the prognosis of patients. As RT-PCR assay can be performed on biopsy specimens obtained before surgery, an evaluation of the TIMP-1 expression in biopsy specimens by RT-PCR may thus provide useful preoperative information on tumour aggressiveness.

Original languageEnglish
Pages (from-to)531-536
Number of pages6
JournalBritish journal of cancer
Issue number4
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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