Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients

Rumiko Taki, Atsunobu Takeda, Hiroshi Yoshikawa, Takako Fukuhara, Ryoichi Arita, Yoko Suehiro, Ilseung Choi, Yuji Kumano, Takao Nakamura, Tatsuro Ishibashi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Purpose: Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan. Methods: The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied. Results: The mean patient age at the onset of ocular involvement was 75.3 years. Four patients had brain involvement. The primary sites were: breast (2); chest (1); testis (1); intestinal tract (1); and nasal sinus (1). In all patients, the cytology of vitreous samples indicated diffuse large B-cell lymphoma (DLBCL). Conclusions: DLBCL is the most common subtype in our study. The prevalence of CNS involvement in patients with SMRL is similar to that with PVRL. The testis and breast may be common sites of origin for SMRL.

Original languageEnglish
Pages (from-to)654-662
Number of pages9
JournalOcular Immunology and Inflammation
Issue number5
Publication statusPublished - Sept 3 2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology


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