Clinical features and pathophysiology of acute esophageal mucosal lesion

Yutaro Ihara, Kazuoki Hizawa, Kouhei Fujita, Yuichi Matsuno, Tsutomu Sakuma, Motohiro Esaki, Mitsuo Iida

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Acute esophageal mucosal lesions (AEMLs) are categorized into black esophagitis (type B) and non-black esophagitis (type NB) on endoscopy. To clarify the distinct pathophysiology, we compared the clinical features and hematological findings at onset among 17 patients with type B esophagitis and 6 patients with type NB esophagitis. In type B esophagitis, time to endoscopy after onset was significantly shorter, and blood levels of lactate, urea nitrogen, creatinine, and glucose were higher than in type NB esophagitis. However, there were no significant intergroup differences in the incidences of other predisposing factors, such as diabetic ketoacidosis or esophageal hernias. These findings suggest that AEMLs are caused by acid reflux and peripheral vascular insufficiency, the latter being more associated with type B esophagitis by its etiology. In addition, blood lactate may indicate the severity of AEML, leading to black esophagitis.

Original languageEnglish
Pages (from-to)642-646
Number of pages5
JournalNihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Issue number4
Publication statusPublished - Apr 1 2016

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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