Clinical evaluation of proton radiotherapy for non-small-cell lung cancer

Yoshiyuki Shioyama, Koichi Tokuuye, Toshiyuki Okumura, Kenji Kagei, Shinji Sugahara, Kiyoshi Ohara, Yasuyuki Akine, Shigemi Ishikawa, Hiroaki Satoh, Kiyohisa Sekizawa

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110 Citations (Scopus)


Purpose: To evaluate the clinical results of proton radiotherapy for patients with non-small-cell lung cancer (NSCLC). Methods and Materials: Between 1983 and 2000, 51 NSCLC patients were treated with proton beams at the University of Tsukuba. There were 28 patients in Stage I, 9 in Stage II, 8 in Stage III, 1 in Stage IV, and 5 with recurrent disease. Thirty-three patients had squamous cell carcinoma, 17 had adenocarcinoma, and 1 had large-cell carcinoma. Median fraction and total doses given were 3.0 Gy (range 2.0-6.0 Gy), and 76.0 Gy (range 49.0-93.0 Gy), respectively. Results: The 5-year overall survival rate was 29% for all patients, 70% for 9 Stage IA patients, and 16% for 19 Stage IB patients, respectively (IA vs. IB: p < 0.05). The 5-year in-field local control rate was higher in patients with Stage IA (89%) when compared with those with Stage IB (39%). Forty-seven patients (92%) experienced acute lung toxicity of Grade 1 or less; 3 had Grade 2, 1 had Grade 3, and none experienced Grade 4 or higher. Patients in the present series showed very little late toxicity. Conclusion: Proton therapy is a very safe and effective treatment for patients with NSCLC, especially for those with early stages. The relative merit of proton therapy in comparison with stereotactic photon radiotherapy or three-dimensional conformal photon radiotherapy remains to be defined through future clinical trials.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number1
Publication statusPublished - May 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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