TY - JOUR
T1 - Clinical association between intraoperative indocyanine green fluorescence imaging pattern, preoperative Gd-EOB-DTPA-enhanced magnetic resonance imaging findings, and histological differentiation in hepatocellular carcinoma
AU - Tomino, Takahiro
AU - Itoh, Shinji
AU - Fujita, Nobuhiro
AU - Okamoto, Daisuke
AU - Nakayama, Yuki
AU - Toshida, Katsuya
AU - Tomiyama, Takahiro
AU - Tsutsui, Yuriko
AU - Kosai, Yukiko
AU - Kurihara, Takeshi
AU - Nagao, Yoshihiro
AU - Morita, Kazutoyo
AU - Harada, Noboru
AU - Ushijima, Yasuhiro
AU - Kouhashi, Kenichi
AU - Ishigami, Kousei
AU - Oda, Yoshinao
AU - Yoshizumi, Tomoharu
N1 - Funding Information:
We thank Yuko Kubota and Miki Nakashima for their technical assistance (Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan), and Edanz for editing a draft of this manuscript. This study was supported by JSPS KAKENHI grant numbers JP-19K09198 and JP-22K15544. The funding sources had no role in the collection, analysis, or interpretation of the data or in the decision to submit the article for publication.
Funding Information:
We thank Yuko Kubota and Miki Nakashima for their technical assistance (Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan), and Edanz for editing a draft of this manuscript. This study was supported by JSPS KAKENHI grant numbers JP‐19K09198 and JP‐22K15544. The funding sources had no role in the collection, analysis, or interpretation of the data or in the decision to submit the article for publication.
Publisher Copyright:
© 2023 Japan Society of Hepatology.
PY - 2023/8
Y1 - 2023/8
N2 - Aim: We aimed to evaluate the association between the intraoperative indocyanine green (ICG) fluorescence imaging (FI) pattern, preoperative magnetic resonance imaging (MRI) findings using gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), preoperative diffusion-weighted imaging (DWI) of MRI, and histological differentiation of hepatocellular carcinoma (HCC). Methods: We retrospectively reviewed the data for 80 tumors of 64 patients. Intraoperative ICG FI patterns were classified into cancerous or rim-positive type. We evaluated the signal intensity ratio of the tumor and the surrounding liver tissue in the portal phase (SIRPP) and intensity in the hepatobiliary phase (HBP) of Gd-EOB-DTPA-enhanced MRI, the apparent diffusion coefficient (ADC) in the DWI of MRI, and clinicopathologic factors. Results: In the rim-positive group, the rate of poorly differentiated HCC and hypointensity type in HBP were significantly higher, and SIRPP and ADC were significantly lower than the rim-negative group. In the cancerous group, the rate of well or moderately differentiated HCC and hyperintensity type in HBP, SIRPP, and ADC were significantly higher than the noncancerous group. Multivariate analysis identified low SIRPP, low ADC, and hypointensity type in HBP as the significant predictive factors for rim-positive HCC and high SIRPP, high ADC, and hyperintensity type in HBP as the significant predictive factors for cancerous HCC. The positive rate of programmed cell death 1-ligand 1 and vessels that encapsulate tumor clusters status of the rim-positive HCC and HCC with low SIRPP were significantly higher than the control group. Conclusions: The intraoperative ICG FI pattern of HCC closely correlated with histological differentiation, preoperative SIRPP and intensity type in the Gd-EOB-DTPA MRI, and preoperative ADC in the DWI of MRI.
AB - Aim: We aimed to evaluate the association between the intraoperative indocyanine green (ICG) fluorescence imaging (FI) pattern, preoperative magnetic resonance imaging (MRI) findings using gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), preoperative diffusion-weighted imaging (DWI) of MRI, and histological differentiation of hepatocellular carcinoma (HCC). Methods: We retrospectively reviewed the data for 80 tumors of 64 patients. Intraoperative ICG FI patterns were classified into cancerous or rim-positive type. We evaluated the signal intensity ratio of the tumor and the surrounding liver tissue in the portal phase (SIRPP) and intensity in the hepatobiliary phase (HBP) of Gd-EOB-DTPA-enhanced MRI, the apparent diffusion coefficient (ADC) in the DWI of MRI, and clinicopathologic factors. Results: In the rim-positive group, the rate of poorly differentiated HCC and hypointensity type in HBP were significantly higher, and SIRPP and ADC were significantly lower than the rim-negative group. In the cancerous group, the rate of well or moderately differentiated HCC and hyperintensity type in HBP, SIRPP, and ADC were significantly higher than the noncancerous group. Multivariate analysis identified low SIRPP, low ADC, and hypointensity type in HBP as the significant predictive factors for rim-positive HCC and high SIRPP, high ADC, and hyperintensity type in HBP as the significant predictive factors for cancerous HCC. The positive rate of programmed cell death 1-ligand 1 and vessels that encapsulate tumor clusters status of the rim-positive HCC and HCC with low SIRPP were significantly higher than the control group. Conclusions: The intraoperative ICG FI pattern of HCC closely correlated with histological differentiation, preoperative SIRPP and intensity type in the Gd-EOB-DTPA MRI, and preoperative ADC in the DWI of MRI.
UR - http://www.scopus.com/inward/record.url?scp=85152917279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85152917279&partnerID=8YFLogxK
U2 - 10.1111/hepr.13902
DO - 10.1111/hepr.13902
M3 - Article
AN - SCOPUS:85152917279
SN - 1386-6346
VL - 53
SP - 723
EP - 736
JO - Hepatology Research
JF - Hepatology Research
IS - 8
ER -
