TY - JOUR
T1 - Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas
T2 - A Nationwide Multicenter Study in Japan
AU - Hanada, Keiji
AU - Kurihara, Keisuke
AU - Itoi, Takao
AU - Katanuma, Akio
AU - Sasaki, Tamito
AU - Hara, Kazuo
AU - Nakamura, Masafumi
AU - Kimura, Wataru
AU - Suzuki, Yutaka
AU - Sugiyama, Masanori
AU - Ohike, Nobuyuki
AU - Fukushima, Noriyoshi
AU - Shimizu, Michio
AU - Ishigami, Kousei
AU - Gabata, Toshifumi
AU - Okazaki, Kazuichi
N1 - Funding Information:
From the *Department of Gastroenterology, Onomichi General Hospital; and †Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima; ‡Department of Gastroenterology, Tokyo Medical University, Tokyo; §Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo; ||Department of Gastroenterology, Hiroshima Prefectural Hospital, Hiroshima; ¶Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya; #Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka; **Faculty of Medicine, First Department of Surgery, Yamagata University, Yamagata; ††Department of Surgery, Kyorin University School of Medicine; and ‡‡Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Kanagawa; §§Department of Pathology, Jichi Medical University, Tochigi; ||||Diagnostic Pathology Center, Hakujikai Memorial Hospital, Tokyo; ¶¶Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka; ##Department of Radiology, Kanazawa University Graduate School of Medical Sciences, Kanazawa; and ***Department of Gastroenterology, Kansai Medical University, Osaka, Japan. Received for publication November 24, 2017; accepted June 8, 2018. Address correspondence to: Keiji Hanada, MD, PhD, Department of Gastroenterology, Onomichi General Hospital, Hiroshima, 1-10-23, Hirahara, Onomichi 722-8508, Japan (e‐mail: kh-ajpbd@nifty.com). This study was supported by the Japan Pancreas Society. The design and conduct of the study, interpretation of the data, and decision to submit the manuscript for publication were the responsibility of the authors listed. The authors declare no conflict of interest. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.pancreasjournal.com). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001114
Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - The aim of this study was to evaluate the clinicopathological features of solid pseudopapillary neoplasms (SPNs). Methods In this retrospective study, 288 SPNs were analyzed. Results Overall, 214 patients (74%) were female. Distant metastases occurred in 4 patients, and splenic vein tumor thrombus occurred in 1 patient. Although imaging findings showed large (>2.0 cm) SPNs with clear, regular border, and heterogeneous internal structure, small SPNs appeared as almost entirely solid. Surgical resection was performed in 278 cases. The 5-year survival rate was 98.8%. Six patients had tumor recurrence after the initial resection. The detection rate in typical pathological findings was low for small SPNs. Tumor extension to the pancreatic parenchyma was detected in greater than 70% of the cases. Tumor invasion to adjacent organs was detected in 13 cases. One was given a diagnosis of apparent high-grade malignant transformation. Conclusions The proportion of male cases was higher than that in previous studies, and there were statistically significant differences in the onset age and tumor diameter between male and female patients. Therefore, women seemed to have an early occurrence of SPNs, suggesting a difference in the developmental stage between men and women. Images and pathological findings of SPNs varied according to tumor size. Our findings indicated that SPN patients have excellent survival after margin-negative surgical resection.
AB - The aim of this study was to evaluate the clinicopathological features of solid pseudopapillary neoplasms (SPNs). Methods In this retrospective study, 288 SPNs were analyzed. Results Overall, 214 patients (74%) were female. Distant metastases occurred in 4 patients, and splenic vein tumor thrombus occurred in 1 patient. Although imaging findings showed large (>2.0 cm) SPNs with clear, regular border, and heterogeneous internal structure, small SPNs appeared as almost entirely solid. Surgical resection was performed in 278 cases. The 5-year survival rate was 98.8%. Six patients had tumor recurrence after the initial resection. The detection rate in typical pathological findings was low for small SPNs. Tumor extension to the pancreatic parenchyma was detected in greater than 70% of the cases. Tumor invasion to adjacent organs was detected in 13 cases. One was given a diagnosis of apparent high-grade malignant transformation. Conclusions The proportion of male cases was higher than that in previous studies, and there were statistically significant differences in the onset age and tumor diameter between male and female patients. Therefore, women seemed to have an early occurrence of SPNs, suggesting a difference in the developmental stage between men and women. Images and pathological findings of SPNs varied according to tumor size. Our findings indicated that SPN patients have excellent survival after margin-negative surgical resection.
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U2 - 10.1097/MPA.0000000000001114
DO - 10.1097/MPA.0000000000001114
M3 - Article
C2 - 30059473
AN - SCOPUS:85051937834
SN - 0885-3177
VL - 47
SP - 1019
EP - 1026
JO - Pancreas
JF - Pancreas
IS - 8
ER -
