"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Yoko Nakamura; Sho Inomata; Makoto Ebine; Yoshiyuki Manabe; Izumi Iwakura; Minoru Ueda

doi:10.1039/c0ob00843e

"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Yoko Nakamura, Sho Inomata, Makoto Ebine, Yoshiyuki Manabe, Izumi Iwakura, Minoru Ueda

Organic and Biological Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We report on the design, synthesis and assessment of a novel biaryl-linked (BArL) molecular probe for the exploration of low-abundant target proteins for bioactive compounds based on the activity based protein profiling (ABPP) approach. Surprisingly, the performance of the BArL probe was better than that of the stepwise tagging approach that is considered to be the most effective method used in ABPP study.

Original language	English
Pages (from-to)	83-85
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1039/c0ob00843e
Publication status	Published - Jan 1 2011

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c0ob00843e

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AU - Iwakura, Izumi

AU - Ueda, Minoru

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"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Abstract

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