Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis

Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto, Takashi Ohshima

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50–70 °C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated.

Original languageEnglish
Pages (from-to)12623-12625
Number of pages3
JournalChemical Communications
Issue number84
Publication statusPublished - Sept 25 2014

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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