Cleansing lotion containing tamarind fruit pulp extract. II. Study of cumulative irritation effects in human

Ratree Maenthaisong, Jarupa Viyoch, Nathorn Chaiyakunapruk, Prateep Warnnissorn

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8 Citations (Scopus)


Background: Cleansing lotion containing extract of tamarind fruit pulp was developed to provide skin a lighter effect. Skin irritation may occur due to keratolytic effect of α-hydroxyl acids (AHA) in the tamarind fruit pulp extract. Objective: To assess the cumulative irritation effect of cleansing lotion containing tamarind fruit extract with 2% (w/w) tartaric acid on human skin compared with placebo product and de-ionized water. Methods:The study design was a single-blinded, randomized side of arm, and controlled study. Three samples, including test product, placebo product, and de-ionized water, were repeatedly applied on the inner forearm of 15 healthy females (aged 28.3 ± 3.1 years) for 30 min daily for 5 days under semi-occlusive patch. Skin irritation was measured by using visual scoring and instruments such as Tewameter® and Mexameter®. All measurements were done before application of samples every day from day 1 until day 5. Final measurements were done after the last application for 3 days (day 8). Results: The results obtained from the visual scoring scale indicated no irritation signs and symptoms of test product. Mean differences of transepidermal water loss and erythema values between test product and de-ionized water and between test and placebo products were not statistically significant (P > 0.05). Conclusions: These findings indicate a preliminary safety evidence of our developed cleansing lotion containing the natural AHAs and can be used as cumulative evidence for supporting the future home use study of this product in human.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of Cosmetic Dermatology
Issue number3
Publication statusPublished - Sept 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology


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